The characters in Real Drive include but are not limited to:
- Masamichi Haru (波留 真理 Haru Masamichi )
- Voiced by: Katsuji Mori
- Age: 81
- The protagonist of the series. A diver of "The Metal" and long time friend of Eiichiro Kushima. Masamichi was in a diving accident while testing an early Meta-Real technology and was in a coma for 50 years before awakening as a paraplegic old man. He eventually regains his ability to walk towards the end of the series.
- Minamo Aoi (蒼井 ミナモ Aoi Minamo )
- Voiced by: Kanae Oki
- Age: 15
- An intern hired by Masamichi Haru and sister of Souta Aoi. Originally hired to replace Holon during a leave for maintenance, she became a permanent employee after she helped guide Masamichi back from a dive gone wrong. Unlike the other humans and some animals in the story, she does not possess a Cyberbrain augmentation, and requires electronic accessories to access The Metal.
- Souta Aoi (蒼井 ソウタ Aoi Sōta )
- Voiced by: Hiroki Takahashi
- Age: 22
- Employee of the EISF and brother of Minamo Aoi. He begins to have feelings for Holon towards the end of the series.
- Holon (ホロン Horon )
- Voiced by: Ayako Kawasumi
- Age: 1
- An android who helps Masamichi Haru with daily life in his old age and assists him in his search for the answer in the sea.
- Eiichiro Kushima (久島 永一朗 Kushima Eīchirō )
- Voiced by: Keiji Fujiwara
- Age: 82
- Director of the EISF and friend of Masamichi Haru. While as old as Masamichi, his body has the appearance of a twenty-eight year old man. It was revealed later in the series that Kushima chose to replace his original body with a prosthetic one, allowing him to continue his work beyond the limits allowed by the human body. He has a spare body to which he transfers his consciousness during his usual body's maintenance, one which might be modeled after the young Haru (Minamo remarked in episode 20 that his spare's appearance reminded her of Haru in his youth).
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